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The GSTP1 rs4147581 is in linkage disequilibrium with rs1695 (D = 0.99, R 2 = 0.44 in Admixed American populations, including Colombians), a common nonsynonymous SNP that changes the 105th amino acid from isoleucine to valine, altering the substrate binding site of GSTP1 38

Many experts agree that topicals should be acidified and possess pH in the range of 4 to 6 to maintain optimal skin health.35 36 37 So we appreciate the fact that the pH of NIODs product is generally within that range

doi: 10.3390/medicina55040088 184 ScarpaMCardinRBortolamiMKotsaftiAScarpaMCPozzaAet al