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Metformin and other drugs used for T2DM, like the SGLT2 inhibitors, may also reduce hyperglycemia-induced elevated endothelial ROS, independent of negative effects on complex 1, such as via inhibition of NADPH oxidase or blocking the entry of glucose into the endothelium (32, 107109, 187, 188) ( Table 2 )

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In a cross-sectional study, mitochondrial fragmentation was specifically observed in the proximal tubules of kidneys from DKD patients

Non-native disulfides are resolved by reduced PDIs, which are regenerated by GSH, leading to the formation of GSSG

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