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Critically, comparable weight loss was not observed in RAMP1/RAMP3 knockout mice, confirming that the effect depends on AMYR and AMYR signaling rather than CTR activation alone

Foundational Research in Diet-Induced Obese Mice The frequently repeated weight and fat findings originate from a short mouse proof-of-concept study

Neuronal activation mapping using cFos immunostaining in the area postrema (AP), nucleus tractus solitarius (NTS), and lateral parabrachial nucleus (LPBN) provided mechanistic insight

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