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Cells were harvested in the plate by centrifugation at 3220 g for 30 min at RT

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This reliance on correlative evidence from disease contexts has reduced CHAC enzymes to mere stress markers and overlooked their potential as dynamically regulated metabolic integrators

Whilst we found that ex vivo vehicle treated cells produced high levels of cytokines, including IL-5, IL-13, IL-9 ( Supplementary Figures 4BD ), and modest amounts of IL-10 and IL-6 ( Supplementary Figures 4E, F ), melatonin treatment greatly reduced the concentration of all cytokines analyzed ( Supplementary Figures 4B F )

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