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INTRODUCTION Psoriasis is a chronic inflammatory skin disorder known to be linked to type 2 diabetes mellitus (T2DM), with 11.6% of psoriasis patients having comorbid T2DM

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However, semaglutide has comprehensively surpassed exenatide in every clinical dimension: weight loss efficacy (approximately 4-5 fold greater), glycemic control (superior in SUSTAIN 3 head-to-head), cardiovascular outcomes (proven superiority vs non-inferiority), dosing convenience (pre-filled pen without reconstitution), and formulation options (oral available)

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- each monomer contains one FAD

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usually improves over several weeks Diarrhoea or constipation : Altered bowel habits due to delayed gastric emptying Abdominal discomfort : Bloating, dyspepsia, or gastro-oesophageal reflux symptoms Practical management strategies recommended by NICE and specialist diabetes services include: Starting at the lowest licensed dose and titrating gradually according to the product's summary of product characteristics Eating smaller, more frequent meals and avoiding high-fat foods Maintaining adequate hydration, particularly if experiencing vomiting or diarrhoea Taking the injection at a consistent time as specified in the SmPC for your particular medication Less common but important adverse effects include: Injection site reactions : Rotate injection sites systematically between abdomen, thigh, and upper arm to minimise localised reactions Hypoglycaemia : Risk increases when GLP-1 agents are combined with insulin or sulphonylureas

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Hence, it lowers inflammation and oxidative stress in the ovarian epithelium

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