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These clinical trials aim to show a reduction in insulin resistance and improved glycemic management when GLP-1s are used in addition to insulin

each one consisting of 2 minutes at 94 C followed by cycles of 94 C for 1 minute, 58 C for 1 minute and 72 C for 1 minute and finally at 72 C for 10 minutes

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The suboptimal in vivo half-life remains a challenge as the short half-life of a peptide reduces its bioavailability that is required for its optimal function 30