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Vitamin B12 is an essential nutrient that plays a crucial role in many bodily functions

Patients who are pregnant or breastfeeding, patients with active malignancy, patients with certain vascular conditions where angiogenesis is a concern, and patients on specific anticoagulants may not be candidates

The obvious downside is volume

However, Gajewicz et al

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Outside the intestines, butyrate exerts potentially useful effects on many conditions, including hemoglobinopathies, genetic metabolic diseases, hypercholesterolemia, insulin resistance, and ischemic stroke (Canani et al., 2011)