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The clinical trial protocol starts at 0.25 mg to 0.3 mg weekly and increases every 4 weeks through escalation steps of 0.6 mg, 1.2 mg, 1.8 mg, and finally 2.4 mg

However, several organs were relatively larger, e.g., liver, brain, kidney, and heart (307, 308)

Suitable only for individuals under medical supervision for pigmentation issues or antioxidant therapy as determined by a qualified healthcare professional

No Withholding Periods

Using available data on the time-dependent transcriptomic changes in enterocytes of these patients, we demonstrate long-term perturbations in their thiamine metabolism, which may be of diagnostic significance