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Prebiotics, probiotics, and dietary interventions have shown promise in preliminary studies, pointing toward the potential for restoring microbial balance and combating dysbiosis [10, 13]

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A previous mediation analysis of semaglutide in adults with overweight or obesity suggested that less than one percentage point of the body weight reduction achieved with subcutaneous semaglutide was attributable to gastrointestinal adverse events (246)

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But participants did not start at their final dose