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489 In families affected by XLID, a number of loss-of-function mutations were found in the GDI1 gene, 490 which encodes a cytosolic protein GDI, the RAB GDP dissociation inhibitor, involved in the control of the guanosine diphosphate (GDP)-bound form of the brain RAB GTPases 491,492 and regulates vesicle dynamics

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The pathophysiology of hair loss often involves the miniaturization of hair follicles, reduced blood supply to the scalp, and inflammation

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Animal models show reduced osteoarthritis progression and improved cartilage quality

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