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Molecular alteration analysis of human gut microbial composition in Graves disease patients

Insulin glargine was increased to 60 units (7% increase) after one month, but again reduced to 54 units alongside up-titration of dulaglutide to 1.5 mg in the second month of therapy

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We noticed, however, that the bottom part of subpocket C in the vicinity of the fragments found in the X-ray structures is formed by the hydrophobic portions of D325, Y479, A481, H538, G483, V469, T471 and is likely to prefer bulky hydrophobic substituents