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Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide and tirzepatide, have emerged as transformative agents for type 2 diabetes and obesity through their potent effects on weight reduction, insulin sensitivity, and cardiovascular outcomes

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This study was a post hoc analysis of a pilot trial conducted between April 2023 and May 2024

The magnitude of difference reflects each drug's biological action

As expected, ingestion of the mixed meal in nonsurgical controls resulted in decreased abundance of multiple lipid species and increased abundance of AAs at 30 minutes, with return to baseline at 120 minutes

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