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Furthermore, the deletion of Bmal1 in the brain induced apoE expression (inhibiting, e.g., astrocytic clearance of A [73]), potentially elucidating how circadian disruption may increase A burden in the brain

The biological functionality of Elamipretide Protein will be determined in the future

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Amphetamines disrupt VMAT2 function and vesicular uptake through a combination of mechanisms: The Weak Base Effect (pH Gradient Collapse) : Amphetamines are lipophilic weak bases (pKa of 9.9) that can readily diffuse across both the plasma and vesicular membranes to accumulate inside synaptic vesicles (Wimalasena 2011)

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May 2001;26(3):221-8