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ERp44 also binds zinc through a histidine cluster, which regulates its retrieval of Ero1 and ERAP1 from the cis -Golgi back to the ER 67

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174 It has been suggested that maintaining a healthy omega-6:omega-3 ratio (closer to 4:1, instead of the more common 20:1 in typical Western diets) may be an effective strategy for reducing inflammation, allergies, and autoimmune reactions