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For instance, pembrolizumab (for certain cancers) had an ICER of ~$236k/QALY, beyond ICERs range ( [44] )

Specifically, patients on GLP-1RA or combination therapy exhibited greater reductions in body mass index (BMI), central systolic blood pressure (SBP), and arterial stiffness as assessed by pulse wave velocity (PWV)

The post says personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 must be evaluated first, and that GLP-1 agonists are contraindicated in those populations regardless of age

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Sublingual peptide delivery has genuine limitations that must be acknowledged and managed