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Resultant oxidative DNA base lesions have the potential to mutate some genetic material, which would impair the integrity of the genome by preventing transcription and replication and by generating mutagenesis (116)

On administration of imipramine, the pkc potentiation of the noradrenaline-cAMP response is attenuated, suggesting that imipramine can directly inhibit pkc activity (Nalepa and Vetulani, 1991)

Primary prevention of cardiovascular and heart failure events With SGLT2 inhibitors, GLP-1 receptor agonists, and their combination in type 2 diabetes

Turner AJ, Whittle SR

Y., Kim, S., Kim, H

The literature is conflicting on whether valepotriates or isovaleric acids, which are believed to have sedative effects, are responsible for valerians calming effects