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GPX4, a selenocysteine-containing enzyme, utilizes GSH to reduce toxic phospholipid hydroperoxides (PL-OOHs) to non-toxic phospholipid alcohols (PL-OHs), thereby disrupting lipid peroxidation chain reactions and preventing oxidative cell injury (Pontel et al., 2022)

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For example, certain GLP1R variants correlate with variable GLP-1 response magnitude and gastrointestinal side effect sensitivity in some populations