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People with very high starting weights may lose more in the initial weeks due to water weight shifts, but this rapid loss does not reflect actual fat loss and does not continue at the same rate

This inflammatory response associated with TMAO is also seen in conditions such as psoriatic arthritis (PsA)

Involvement in the fat metabolism of the mitochondria

Epidemiological studies show patients with fatty liver have higher rates of kidney stones, and vice versa, but this reflects association rather than causation