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Early studies find retroviral transduction of the human G6PD gene into mouse and human hematopoietic stem cells resulted in stable lifelong expression of human G6PD in primary and secondary bone marrow transplant recipient mice, increasing G6PD activity two-fold [117]

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Further investigations and large-scale clinical trials need to confirm its effects and safety in humans

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Isolated islets were cultured in RPMI 1640 medium (Hyclone, South Logan, UT, USA) with 11.1 mM glucose (Solarbio, Beijing, China) and 10% fetal bovine serum (Gibco, Grand Island, NY, USA) supplemented with 1% penicillin and streptomycin under 37 C and 5% CO 2 conditions