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Strategies to correct the incretin defects in patients with type 2 diabetes include replacement of GLP-1 with a long-acting analog that resists degradation and development of drugs that inhibit the enzyme DPP-4, which breaks down GLP-1

Renard E, Schaepelynck-Blicar P (2007) Implantable insulin pumps

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Most researchers beginning retatrutide start with one or two 5mg vials for the first month, then transition to 10mg or 20mg vials as the dose escalates

doi: 10.1016/j.bbrc.2004.01.085

Non-nutrient promoters of GIP secretion include oral administration of ZnCl 2 to non-fasted mice, which increases GIP secretion 26% via K cell expression of GPR39 (Moran et al., 2019)