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Methods A literature search was conducted in PubMed and Embase in December 2020 using the search terms scalp AND psoriasis AND (patient preference treatment OR topical OR corticosteroid OR intralesional corticosteroid OR vitamin D analogue OR keratolytic OR salicylic acid OR urea OR methotrexate OR cyclosporine OR acitretin OR etanercept OR adalimumab OR brodalumab OR ixekizumab OR secukinumab OR guselkumab OR infliximab OR certolizumab OR ustekinumab OR risankizumab OR mirikizumab OR apremilast OR phototherapy OR comb OR coal tar)

What a COA Should Include Identity Confirmation Mass spectrometry confirming 159.19 Da (5-amino-1-methylquinolinium cation) or the labeled salt form mass NMR or LC-MS sequence verification Structural identity vs related quinoline NNMT inhibitors Purity Testing HPLC purity at 98%+ (achievable for a small molecule) Single dominant peak