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Tolerance (i.e., need for increased amounts or diminished effect with continued use of the same amount)* Experiencing withdrawal (opioid withdrawal syndrome) or taking opioids (or a closely related substance) to relieve or avoid withdrawal symptoms.* *Patients who are taking opioids as prescribed by a healthcare provider may experience tolerance and withdrawal, but in that case, do not have opioid use disorder

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS, et al