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It is important to approach this question carefully, distinguishing between what clinical trial data has formally reported, what has been observed anecdotally, and what remains biologically plausible but unconfirmed

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Subsequent studies demonstrated that apelin signaling is highly context dependent, with differential coupling to G_i, G_q, and -arrestin pathways depending on ligand structure, receptor density, and tissue environment (Murali and Aradhyam, 2023)

Back Richmond, C (30 June 2006) 'Dr Ellis Samols', The Independent

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