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Activation of caspase-1 by inflammasomes induces pyroptosis, an inflammatory form of programmed cell death (Wroska et al., 2024)

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GLP-1 RAs not only ameliorate insulin resistance and microvascular injury [84], which are significant determinants of depression in T2DM, but also enhance dopamine metabolism and stimulate growth factor signaling pathways, suggesting potential neuroprotective functions [85,86]