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The IGFs system is involved in the regulation of cancer progression through a variety of signaling pathways, including the MAPK signaling pathway (18), the PI3K/AKT/mTOR signaling pathway (19) and the NF-B signaling pathway (20)

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Combination therapy with anti-PD-L1 and compound 968 results in increased secretion of granzyme B, CXCL10, and CXCL11 by CD4 + and CD8 + T cells, thereby bolstering CD3 + T cell infiltration into tumor microenvironments [202]

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doi: 10.1128/jvi.68.8.5063-5073.1994

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