The release of cytokines and autoantibodies are reported in antithyroid drugs-treated patients and/or laboratory animals.56,59 It has been shown that cytokine-mediated liver injury could has a critical role in methimazole-treated mice.56 Furthermore, some cases of PTU-induced hepatic damage are reported in which autoantibodies are demonstrated.60 Lymphocyte sensitization in a patient with neonatal liver injury probably by placental transfer of PTU has been reported.61 All these reports are in line with the hypothesis that patient immune system might play a role in the pathogenesis of hepatic injury induced by antithyroid medications
Over time, poorly controlled diabetes significantly increases the risk of serious complications such as cardiovascular disease, diabetic retinopathy, nephropathy, and neuropathy
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In the event of an overdose, it is reasonable to employ the usual supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring (including obtaining an electrocardiogram), and institute supportive therapy as indicated by the patient's clinical status
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Physiology, Female Reproduction. StatPearls, StatPearls Publishing, 2023, Treasure Island (FL)
