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J Chem Neuroanat (2002) 24(4):22542

The evidence supports gut microbiota as relevant to GLP-1 production but does not validate probiotics as a reliable method for significantly increasing GLP-1

GLP-1 directly activates POMC/CART neurons and indirectly inhibits, via GABAergic transmission, the neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, which collectively results in signals that reduce food intake

Anderson, K

Persistent bleeding over multiple bowel movements, bleeding that increases in volume rather than resolving, or new-onset bleeding in patients aged 45 or older should trigger urgent medical assessment

As prescribing continues to rise, awareness of GLP-1 dermatologic effects ensures safer therapy and more confident patient counseling