Some studies have reported that knockdown of GLP-1R in ARC POMC neurons didnt alter body weight or composition, food intake, and energy expenditure, nor did it significantly alter the reduction of food intake by intraperitoneal (i.p.) exendin-4 [80]
The risk-reward, given the evidence base, doesnt pencil out
However, as individuals search for ways to minimize side effects and manage costs, microdosing has surfaced as a potential alternative
For a 10 mg vial, the standard reconstitution choices are: 10 mg + 1 mL BAC water yields a concentration of 10 mg/mL, or equivalently 10000 mcg/mL
NewSelf offers only compounded semaglutide and tirzepatide, which are not FDA-approved as finished products
Intramuscular B12 injections yielded minimal benefit