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In some circumstances, focused radiation or a GH antagonist such as pegvisomant may be employed to shrink the tumor or block function

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Most of the core clock genes ( CLOCK, PER1, PER2, CRY3, NRLD2 ) showed the difference of expression oscillation in the pituitary of GH transgenic and wild type coho salmon, which indicated that the GH gene might have a regulatory effect on the expression of pituitary clock genes