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You have tolerated the current dose with minimal or no GI side effects for at least two consecutive weeks

Gut microbiota: An important link between western diet and chronic diseases

It may worsen symptoms in a folate-sensitive undermethylator or when other methylation impediments are present

Establishing a consistent bathroom routine, particularly after breakfast when the gastrocolic reflex is strongest, helps maintain regularity

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Current insight into the cardiovascular biology of GIP is limited, and findings in preclinical and clinical studies point in different directions, ranging from potentially cardioprotective effects to heightened vascular inflammation and artherogenesis 24,25