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Standard maintenance for most menopausal hot flash management is 0.05 mg/day, applied twice weekly or once weekly depending on the brand

The NHS criteria are stricter, and lower BMI thresholds apply for South Asian, Chinese, Other Asian, Middle Eastern, Black African, and African-Caribbean backgrounds 3

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The study describes the results of the BELIEVE trial, led by Dr Steven Heymsfield of the Pennington Biomedical Research Center

The body's absorption mechanism involves intrinsic factora glycoprotein secreted by gastric parietal cellswhich facilitates absorption of approximately 1.52 micrograms per meal in the terminal ileum, with additional amounts absorbed through passive diffusion at about 1% of the remaining dose