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However, the isoform A (exon 11-splice variant) of IR (IR-A), normally expressed in fetal tissues, promotes cell growth in response to IGF-2 stimulation and has been reported to be abundantly expressed in some IGF-1R deficient leiomyosarcomas (Sciacca et al, 2002)

doi: Nicolau, J., Blanco-Anesto, J., Bonet, A., et al

Small 16 , 1902242 (2020)

In circumstances where patients cover the cost of treatment, where reimbursement is restricted, or when insurance coverage is limited, the financial expense may influence selection of GLP-1 RA therapy [123]

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The current public schedule is: TRIUMPH-1: general obesity, 80-week treatment duration, the largest TRIUMPH trial, pivotal for the NDA filing