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The addition of glucagon-receptor activity the structural feature distinguishing retatrutide from dual GIP/GLP-1 agonists such as tirzepatide is studied in research models for its role in energy expenditure and hepatic lipid metabolism

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A greater percentage of patients who received RYBELSUS 14 mg once daily (8%) and RYBELSUS 7 mg once daily (4%) discontinued treatment due to gastrointestinal adverse reactions than patients who received placebo (1%)