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A primary drawback of subcritical water extraction is the requirement for high temperatures, typically between 100C and 374C, which can cause thermal degradation of heat-sensitive polyphenolic compounds, thereby reducing their yield and bioactivity (66)

Adewunmi, O., Shen, Y., Zhang, X

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Melatonin as an Anti-Aging Therapy for Age-Related Cardiovascular and Neurodegenerative Diseases