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Kobayashi S, Sato M, Kasakoshi T, Tsutsui T, Sugimoto M, Osaki M et al (2015) Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function

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Injectable protocols reach 10 to 20x the tissue concentration of topical application

Kevin J Lenton, Alain T San, Hlne Therriault, Andr M Cantin, Hlne Payette, J Richard Wagner - Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency - Am J Clin Nutr - 2003 Jan

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These data allow us to conclude that mitochondrial LPO is not sufficient for ferroptosis and that cytosolic ROS mediates additional oxidative events that stimulate ferroptosis in conjunction with mitochondrial LPO