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Unlike prior studies of AMD development that were limited to patients with diabetes, the authors wrote in their paper, their findings suggest that GLP-1 drugs "may be associated with reduced risk even in individuals with obesity but not diabetes, potentially supporting a protective benefit independent of glycemic control and mitigating diabetes as a confounding factor.

Semaglutide is available as a branded injection like Ozempic (approved for type 2 diabetes) or Wegovy (approved for chronic weight management)

Some patients report that the compounded formulation seems gentler on their stomach compared to their experience with brand-name tirzepatide, though whether this is due to the niacinamide, different excipients, or placebo effect remains unclear

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