Dynamic regulation of mitochondrial fission through modification of the dynaminrelated protein Drp1
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demonstrated that AC synergistically enhanced the cytotoxic abilities of 5-FU, caused G1 cell cycle arrest, and promoted apoptosis by modulating the anti-apoptotic B-cell lymphoma 2 (Bcl2) and the pro-apoptotic Bcl-2-associated X protein (Bax), and to a lesser degree, Bcl-xL and p53
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