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Every comparative claim in this article therefore carries a caveat: it is either an indirect comparison across trials with different populations, dosing schedules, and endpoints, or it is a mechanistic extrapolation from preclinical and Phase 2 data

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This could be explained by the strategic metabolic downregulation to preserve important functions for survival while minimizing cell damage (Traxler et al., 2011

doi: 10.1007/S11154-023-09807-3 13 MarsoSPDanielsGHBrown-FrandsenKKristensenPMannJFENauckMAet al