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Case studies highlight how this approach can work in real life

Their use can be proposed as alternatives for patients who may not undergo surgery, as a bridge to optimize outcomes before or in association with surgery

For example, 4-HNE can induce the activation of transcription factor such as nuclear factor kappa light chain enhancer of activated B cell (NF-B) and hypoxia induced factor-1 alpha (HIF-) to mediate pro-survival and angiogenic signals [58, 59]

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doi:10.3389/fcimb.2022.915701 118. Tk, I., Staruk, Z., Choi, I.-Y., & Gruetter, R

This natural stimulation approach results in moderate GH levels that follow normal circadian patterns