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Furthermore, a recent report (410) examined the effect of RYGB on lean pigs, and indicates how it is the post-operative GLP-1 (9-36) NH2 levels that raise, while surprisingly the active (7-36) NH2 peripheral levels were reduced

The pharmacokinetic enhancement attenuated the peak of drug exposure combining with less dependence on GLP-1mediated pharmacology, and avoided the gastrointestinal adverse reactions of selective GLP-1 receptor agonist

This allows patients to stay connected with the medical team while receiving guidance, treatment monitoring, and support from home

Accessed June 28, 2026.

The article states that GLP-1 therapy after cholecystectomy is not contraindicated, but that it warrants closer monitoring than in patients whose gallbladder is intact