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In the first hour after excision of the skin, under a laminar flow hood and under sterile conditions, the skin explants were washed with a PBSantibiotic solution, and the subcutaneous fat and lower dermis were mechanically removed using a surgical scarpel
The increment in intestinal permeability is another prominent mechanism in the gut-brain axis communication in patients with migraine, leading to inflammation and the release of pro-inflammatory cytokines (200, 201)
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