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NHS approach to B12 deficiency: NICE Clinical Knowledge Summaries recommend investigating B12 deficiency in patients presenting with macrocytic anaemia, unexplained neurological symptoms, or risk factors including pernicious anaemia, gastrectomy, malabsorption disorders, metformin use, proton pump inhibitors, or nitrous oxide exposure

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(AP Photo/Kirsty Wigglesworth) A Fan wears a T-Shirt with a picture of singer Lemmy Kilmister to commemorate the Motorhead frontman in Burslem, Stoke on Trent, England, Friday, May 9, 2025

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doi: 10.1111/j.1365-2265.2010.03853.x 59 FarholtSSode-CarlsenRChristiansenJSstergaardJRHybyeC