Maintain 6 mg for at least 8-12 weeks to assess response before considering further escalation
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Internet: (accessed 26 January 2026) Gillett G, Shivakumar N, James A, and Salmon J
This may also increase cocaine's cardiotoxicity
Benefits Mimics natural human growth hormone Reduces visceral fat, significantly diminishing abdominal fat Increases lean muscle mass Reduces liver fat in NAFLD Improves lipid profile when taken over 6 12 months Improves cognition related to age-related GH/IGF-1 decline Dosing Subcutaneous 1,000 mcg 2,000 mcg Once daily At bedtime 12 weeks ON
You should contact your GP or diabetes care team if: Cold sensitivity is severe, persistent, or progressively worsening You experience cold intolerance accompanied by other symptoms such as extreme fatigue, constipation, dry skin, hair loss, or unexplained weight gain You develop symptoms suggestive of hypothyroidism (underactive thyroid), which can cause cold sensitivity (note that while GLP-1 receptor agonists have been associated with C-cell tumours in rodent studies, there is no established link to hypothyroidism in humans) You notice signs of anaemia, such as pallor, breathlessness, or palpitations, which can cause cold sensitivity Cold hands or feet are accompanied by colour changes (white, blue, or red), pain, or numbness, which may indicate circulatory problems You experience unexplained fever, chills, or rigors, which could suggest infection You have symptoms of hypoglycaemia (low blood sugar) such as shakiness, sweating, or confusion, especially if you also take insulin or sulfonylureas NICE guidance (NG28) recommends regular monitoring of patients on GLP-1 receptor agonists, including assessment of glycaemic control, weight, and tolerability
