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GLP1/E therapy led to upregulation of pathways involved in autophagy and vesicle-mediated transport, suggesting that this intervention enhances hypothalamic autophagy, a mechanism that may contribute to the metabolic improvement observed in GLP1/E-treated animals

When fibre is fermented by gut bacteria, it produces short-chain fatty acids, which have been shown to stimulate GLP-1 secretion in the gut

The article lists personal history of medullary thyroid carcinoma, MEN2 syndrome, severe renal impairment, and active diabetic retinopathy complications

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Abd El Aziz MS, Kahle M, Meier JJ, Nauck MA

Approval Timeline The developer of retatrutide is expected to file for FDA review by the end of the year, following the completion of phase 3 trials