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Informing a priori sample size estimation in qualitative concept elicitation interview studies for clinical outcome assessment instrument development

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Eli Lilly's May 21, 2026 announcement reported mean body-weight reduction of 19.0% on 4 mg, 25.9% on 9 mg, and 28.3% on 12 mg, compared with 2.2% on placebo [1][2]

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Starts at 1 mg and builds slowly through 4 mg before increasing