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Retatrutide is a triple agonist: it works on three (GLP-1, GIP, and glucagon)

However, a crucial limitation of the above studies is that the endpoint was pathologic (described as asymptomatic chronic pancreatitis), referring to histologic changes, rather than clinical 26

They may bleed, but theyre more often painful and itchy

Moran, C.D

The glucagon receptor activation in Retatrutide may provide slight advantages for body composition