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Metabolic reprogramming, which leads to effects such as a higher oxygen consumption rate (OCR) and altered glutamine and glucose metabolism in cells, contributes to the cells resistance to venetoclax and ibrutinib (17)

Future perspectives of NADs development Although many NADs have shown promising preclinical results, the number of NADs approved by the FDA for clinical use remains limited

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Despite these limitations, the study has several strengths

Results achieved from EmSculpt treatments can be maintained with regular diet and exercise