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Human dermal fibroblast studies show up to 70% increase in collagen production at optimal 1 nanomolar concentration, with collagen IV showing 25.4-fold increase when combined with hyaluronic acid

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It has a pharmacological rationale

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Another technical limitation concerns the possibility that the PFC voxel, although carefully positioned to avoid ventricular spaces, may include a small fraction of CSF within the interhemispheric fissure

S., Dukes, A