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2 For example, hepatotoxicity of acetaminophen is caused by the production of a highly reactive intermediate oxygen metabolite (N-acetyl- p -benzoquinoneimine)

Despite these suboptimal geometries, both chimeras retained potent degrader activity (see previous section), suggesting that degradation efficacy is not strictly dependent on interface energy or complex geometry

Future research should investigate long-term outcomes in high-risk populations, direct comparisons between physiological and pharmacological dosages, cost-effectiveness analyses, and adherence metrics to inform optimal strategies for the prevention and management of vitamin B12 deficiency

doi: 10.1093/molehr/gap059 68 SmithLBWalkerWH

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