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Its small molecular size allows it to penetrate intestinal epithelial cells directly, which is why it has attracted research interest as an orally deliverable gut-targeted compound

They are given as weekly injections via pre-filled pens that can be self-administered into the upper arm, thigh or stomach

Its neuroprotective effects are mediated through multiple pathways, including vascular regeneration, neuroinflammation modulation [125], and regulation of calcium signaling and neurotransmission [126]

High B12 without supplementation is a different clinical picture entirely

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17 : 25962606 Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K and Gotoh Y (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways